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Curr Opin Biotechnol. 1997 Apr 1;8(2):215-20.

Mechanisms and applications of pathogen-derived resistance in transgenic plants.

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Division of Plant Biology BCC 206 The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA


Genes that confer viral pathogen-derived resistance (PDR) include those for coat proteins, replicases, movement proteins, defective interfering RNAs and DNAs, and nontranslated RNAs. In addition to developing disease-resistant plant varieties for agriculture, PDR has increased the understanding of viral pathogenesis and disease. Furthermore, significant advances in elucidating the fundamental principles underlying resistance will lead to second and third generation genes that confer increased levels of sustainable resistance.

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