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Fold Des. 1996;1(2):R27-30.

Protein folding from a combinatorial perspective.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139-4307, USA. bobsauer@mit.edu

Abstract

Combinatorial mutagenesis experiments show the existence of many different solutions to the problem of complementary packing of non-polar sidechains in the protein core. They suggest that a significant amount of structural information is carried by the simple pattern of polar and non-polar residues along the polypeptide chain, indicate that the formation of buried polar interactions may be a fundamentally slow step in protein folding and show that proteins with many native properties occur at reasonable frequencies in random sequence libraries.

PMID:
9079366
DOI:
10.1016/S1359-0278(96)00015-6
[Indexed for MEDLINE]
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