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Immunol Today. 1997 Mar;18(3):140-5.

Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH.

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Dept of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-9040, USA. LIPTON@UTSW.SWMED.EDU


alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of alpha-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after infection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through alpha-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from alpha-MSH receptors on neurons within the brain.

[Indexed for MEDLINE]

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