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Immunol Today. 1997 Mar;18(3):115-20.

The function of costimulatory molecules and the development of IL-4-producing T cells.

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Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.


The development of IL-4-producing effector T cells during a type 2 immune response requires signaling through B7 ligands, but probably not CD40 ligands. Here, William Gause and colleagues review the still controversial role of CD28 and CTLA-4 on T cells, and B7-1 and B7-2 on antigen-presenting cells, and provide a model to incorporate recent findings.

[Indexed for MEDLINE]

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