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Cancer Genet Cytogenet. 1997 Mar;94(1):67-72.

Telomere dynamics and cytogenetic changes in human hematologic neoplasias: a working hypothesis.

Author information

1
First Department of Internal Medicine, Tokyo Medical College, Japan.

Abstract

Chromosome termini, termed telomeres, provide important protection to avoid loss of master gene(s) that may exist at subtelomeric regions. Moreover, erosion of telomeres by cell division through end-replication problems resulted in telomeric-associated cytogenetic aberrations. To maintain a telomere length related to cell immortality, telomerase activity is upregulated in cancer cells, therefore, telomerase is considered to be a new marker of neoplasias. In this paper, we review and make suggestions regarding key aspects of telomere dynamics in both normal hematopoiesis and in malignant hematologic diseases.

PMID:
9078293
[Indexed for MEDLINE]

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