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Eur Urol. 1997;31(2):209-15.

A genetic sequence change in the 3'-noncoding region of the androgen receptor gene in prostate carcinoma.

Author information

1
Urology Department, Assaf Harofeh Medical Center, Zerifin, Israel.

Abstract

OBJECTIVE:

We intended to identify structural changes in the hormone-binding domain and C-terminal region of the androgen receptor (AR) gene in carcinoma of prostate specimens.

METHODS:

Twelve prostate cancer specimens from prostate resections were analyzed for the presence of mutations in the E-H exons and part of the 3'-untranslated region of the AR cDNA, using RT-PCR and direct sequencing.

RESULTS:

A polymorphic sequence spanning 17 nucleotides was identified in the 3'-untranslated region of the AR cDNA from one prostate carcinoma tissue, suggesting the presence of a somatic mutation. No mutations were identified in the coding sequence of the hormone-binding domain of the AR cDNA.

CONCLUSION:

These results suggest that AR mutations are probably uncommon molecular events in the early stages of prostate cancer.

PMID:
9076468
DOI:
10.1159/000474452
[Indexed for MEDLINE]

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