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Genome Res. 1997 Mar;7(3):210-22.

X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content.

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Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.


A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 [XIST] and Xq21.3 XY homology loci.

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