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Curr Biol. 1997 Jan 1;7(1):R38-40.

Neurotrophins: the yin and yang of nerve growth factor.

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School of Biological and Medical Sciences, University of St. Andrews, St. Andrews, Fife KY16 9TS, Scotland, UK.


In the fifty years since its discovery, a substantial body of work has established that nerve growth factor plays a key role in promoting the survival of neurons during development; the recent demonstration that it can also promote cell death therefore comes as a surprise.

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