Send to

Choose Destination
Biochem Biophys Res Commun. 1997 Feb 24;231(3):651-4.

Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors.

Author information

Institute for Metabolic Disorders, Bayer Corporation, West Haven, Connecticut 06516, USA.


We have used PCR with degenerate oligonucleotide primers to clone novel members of the G protein-coupled receptor (GPCR) superfamily. We report here a novel gene, CEPR, which encodes a candidate receptor that is most similar to the peptide receptor family. The coding region of the human CEPR gene predicts a seven transmembrane domain (TM) receptor of 375 amino acids. CEPR has 28-30 percent amino acid identity to angiotensin II and interleukin 8 receptors, and slightly lower percent identity to many other GPCRs. Northern blot analysis reveals a 3.3 kb CEPR transcript in different regions of human brain and in various peripheral tissues. The ubiquitous tissue distribution of CEPR, its expression in early development, and its conservation in evolution indicate a potentially important biological function for this receptor and its putative peptide ligand.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center