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Br J Obstet Gynaecol. 1997 Feb;104(2):241-5.

The role of endogenous nitric oxide synthesis in contractility of term or preterm human myometrium.

Author information

1
Division of Obstetrics and Gynaecology, UMDS, St Thomas' Hospital, London, UK.

Abstract

OBJECTIVE:

To assess in vitro the role of endogenous myometrial nitric oxide synthesis on human myometrial contraction.

DESIGN:

Strips of myometrium were mounted in a standard organ bath for assessment of isometric contraction and the response to modulators of nitric oxide synthesis determined.

SETTING:

A teaching hospital research laboratory.

SAMPLE:

Women undergoing elective nonlabour caesarean section under regional anaesthesia: 54 at term and seven preterm.

RESULTS:

Neither addition of L-arginine, the substrate for nitric oxide synthase, nor of an inhibitor of nitric oxide synthase led to any specific change in spontaneous myometrial contraction.

CONCLUSION:

Endogenous nitric oxide production does not play an important role in the control of human term of preterm nonlabouring uterine smooth muscle contractility.

PMID:
9070147
[Indexed for MEDLINE]

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