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Curr Opin Cell Biol. 1997 Apr;9(2):233-9.

The state of the STATs: recent developments in the study of signal transduction to the nucleus.

Author information

1
Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Abstract

The STATs (signal transducers and activators of transcription) are latent cytoplasmic proteins that, upon activation by cell surface bound polypeptide ligands, move to the nucleus to direct transcription. A variety of protein-protein interactions that affect the function of STATs has been recently recognized. It has become clear that the STATs are functional mosaics, or mixtures of signal transduction and transcription modules.

PMID:
9069254
DOI:
10.1016/s0955-0674(97)80067-1
[Indexed for MEDLINE]

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