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Curr Opin Cell Biol. 1997 Apr;9(2):134-42.

How receptors talk to trimeric G proteins.

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Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.


Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.

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