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Curr Opin Cell Biol. 1997 Apr;9(2):134-42.

How receptors talk to trimeric G proteins.

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1
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA. hbourne@quickmail.ucsf.edu

Abstract

Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.

PMID:
9069253
[Indexed for MEDLINE]
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