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Curr Opin Cell Biol. 1997 Apr;9(2):143-7.

A new family of G-protein regulators - the RGS proteins.

Author information

1
Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, PO Box 9812, New Haven, CT 06536, USA. Michael.Koelle@Yale.edu

Abstract

Genetic experiments have recently been used to identify a family of 'regulator of G-protein signaling' (RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The first biochemical studies of RGS proteins have shown that they accelerate the GTPase activities of G-protein alpha subunits, thus driving G proteins into their inactive GDP-bound forms. The physiological significance of the large number of different RGS proteins remains to be explored.

PMID:
9069252
DOI:
10.1016/s0955-0674(97)80055-5
[Indexed for MEDLINE]

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