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J Antibiot (Tokyo). 1997 Jan;50(1):22-6.

Targeted screening for elongation factor Tu binding antibiotics.

Author information

1
Lepetit Research Center, Gerenzano (VA), Italy.

Abstract

The development of a screen targeted to antibiotics which bind elongation factor Tu (EF-Tu) is described. The method was based on selection of antimicrobial activities which were antagonized by exogenous EF-Tu. Kirromycin, a known inhibitor of EF-Tu, was positive in this screen. Among 47,000 microorganisms screened, several producers of kirromycin-type antibiotics were detected and the novel antibiotics GE2270 and GE37468 were discovered. These thiopeptide molecules constitute, along with amithiamycin, a novel class of antibiotics acting on EF-Tu.

PMID:
9066762
DOI:
10.7164/antibiotics.50.22
[Indexed for MEDLINE]
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