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Trends Biochem Sci. 1997 Mar;22(3):93-7.

Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.

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Department of Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.


Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

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