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Trends Biochem Sci. 1997 Mar;22(3):77-80.

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

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Institute of Biomedical and Life Sciences, University of Glasgow, UK.


The retinoblastoma protein, RB, is an important tumour suppressor. Recent studies have shown that it inhibits the synthesis of both rRNA and tRNA by RNA polymerases I and III. Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression.

[Indexed for MEDLINE]

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