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Trends Biochem Sci. 1997 Mar;22(3):77-80.

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

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1
Institute of Biomedical and Life Sciences, University of Glasgow, UK. rwhite@udcf.gla.ac.uk

Abstract

The retinoblastoma protein, RB, is an important tumour suppressor. Recent studies have shown that it inhibits the synthesis of both rRNA and tRNA by RNA polymerases I and III. Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression.

PMID:
9066256
[Indexed for MEDLINE]
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