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J Pediatr. 1997 Mar;130(3):394-9.

Septicemia caused by Salmonella infection: an overlooked complication of sickle cell disease.

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1
Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica.

Abstract

OBJECTIVES:

To describe the characteristics of salmonella infections in sickle cell disease and to compare the features of osteomyelitis and those with bacteremia/septicemia without obvious bone changes. To search for risk factors for osteomyelitis, and to draw attention to the frequency and significance of salmonella bacteremia/septicemia.

STUDY DESIGN:

A retrospective review of all salmonella isolations from the blood, pus, or aspirates during a 22-year period.

SETTING:

The sickle cell clinic at the University Hospital of the West Indies, Kingston, Jamaica.

SUBJECTS:

Patients with all genotypes of sickle cell disease. Incidence data and the frequency of associated cholelithiasis were derived from the cohort study based on follow-up of all children detected by neonatal screening.

MAIN OUTCOME MEASURES:

Osteomyelitis and bacteremia/septicemia.

RESULTS:

Of 55 patients with salmonella infections, 25 initially had osteomyelitis and 27 had bacteremia/septicemia. Three of the first group later had bacteremias for a total of 30 episodes of bacteremia/septicemia, and 4 of the second group later had osteomyelitis for a total of 32 episodes of osteomyelitis. The incidence of salmonella infection was 8.6% by 15 years, and 96% of infections occurred before the age of 10 years. Preceding episodes of avascular necrosis of bone were more frequent (p < 0.006) in patients with osteomyelitis. Patients with osteomyelitis were not more prone to gallstones. High fever (temperature > or = 40 degrees C or 104 degrees F) occurred in 41%, and occasionally marked bone marrow suppression mimicked the aplastic crisis. Twenty Salmonella serotypes were isolated; Salmonella enteritidis accounted for 36% of infections, but no serotype difference occurred between those with osteomyelitis and those with bacteremia/septicemia. There were no deaths in the 32 patients with osteomyelitis, but 7 (23%) of 30 patients with septicemia died.

CONCLUSIONS:

Anti-salmonella prophylaxis requires assessment in the management of bone necrosis. Anti-salmonella agents may be indicated in undiagnosed septic conditions in sickle cell disease pending culture results.

PMID:
9063414
[Indexed for MEDLINE]
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