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J Pineal Res. 1997 Jan;22(1):42-4.

The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans.

Author information

1
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.

Abstract

A physiological dose of melatonin (0.5 mg) or placebo was given at bedtime to night shift workers (n = 21) for seven days, and endogenous melatonin profiles were measured on the eighth day. The amplitude of endogenous melatonin secretion was unchanged by treatment. Also, a melatonin treatment trial using a 50 mg daily bedtime dose for 37 days to a blind subject resulted in no change in the endogenous melatonin profile. We conclude that circulating melatonin can shift the phase, but does not alter the amplitude, of pineal melatonin secretion.

PMID:
9062869
[Indexed for MEDLINE]

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