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J Pineal Res. 1997 Jan;22(1):42-4.

The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans.

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Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.


A physiological dose of melatonin (0.5 mg) or placebo was given at bedtime to night shift workers (n = 21) for seven days, and endogenous melatonin profiles were measured on the eighth day. The amplitude of endogenous melatonin secretion was unchanged by treatment. Also, a melatonin treatment trial using a 50 mg daily bedtime dose for 37 days to a blind subject resulted in no change in the endogenous melatonin profile. We conclude that circulating melatonin can shift the phase, but does not alter the amplitude, of pineal melatonin secretion.

[Indexed for MEDLINE]

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