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Immunol Rev. 1997 Feb;155:145-54.

Arousal and inhibition of human NK cells.

Author information

1
DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA. lanier@dnax.org

Abstract

NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.

PMID:
9059890
[Indexed for MEDLINE]

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