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Am J Nephrol. 1997;17(1):1-11.

The 1996 Massry Prize. Inositol trisphosphate and calcium: two interacting second messengers.

Author information

1
Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK. mjb38@cus.cam.ac.uk

Abstract

Inositol trisphosphate (InsP3) functions as a second messenger to control the release of internal calcium and the entry of external calcium. This InsP3/Ca2+ signalling pathway is based on a hierachical system with the release from individual channels being the fundamental event (Ca2+ blips). A collection of blips produces larger elementary events (Ca2+ puffs) which then fuse through a regenerative process of calcium-induced calcium release to give global events (Ca2+ waves). This highly versatile signalling system has been adapted to regulate a wide range of cellular processes including fertilization, development, proliferation and apoptosis.

PMID:
9057946
DOI:
10.1159/000169064
[Indexed for MEDLINE]

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