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J Med Chem. 1997 Feb 28;40(5):819-24.

Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.

Author information

1
Abbott Laboratories, Abbott Park, Illinois 60064, USA.

Abstract

Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to design selective 5-lipoxygenase (5-LO) inhibitors. Replacement of the NSAID carboxylic acid group with a N-hydroxyurea group provided congeners with selective 5-LO inhibitory activity.

PMID:
9057869
DOI:
10.1021/jm9606150
[Indexed for MEDLINE]

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