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Immunol Today. 1997 Feb;18(2):72-6.

Cellular environments and apoptosis: tissue microenvironments control activated T-cell death.

Author information

1
Dept of Clinical Immunology, Royal Free Hospital School of Medicine, Hampstead, London, UK. akbar@fhsm.ac.uk

Abstract

Activated T cells must be removed by apoptosis at the end of an immune response in order to maintain cellular homeostasis. Although recent attention has focused on the role of CD95 (Fas/APO-1) in the elimination of activated T cells, apoptosis can also be induced by cytokine deprivation. Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments.

PMID:
9057357
DOI:
10.1016/s0167-5699(97)01003-7
[Indexed for MEDLINE]

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