Abstract
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / therapeutic use
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Animals
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Antifungal Agents / administration & dosage
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Antifungal Agents / therapeutic use*
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Brain / microbiology
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Brain Diseases / drug therapy*
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Brain Diseases / microbiology
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Colony Count, Microbial
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Dose-Response Relationship, Drug
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Female
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Meningitis, Cryptococcal / drug therapy*
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Meningitis, Cryptococcal / microbiology
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Mice
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Polyenes / administration & dosage
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Polyenes / therapeutic use
Substances
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Antifungal Agents
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Polyenes
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partricin
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Amphotericin B