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J Clin Psychiatry. 1997 Jan;58(1):12-5.

Divalproex treatment of disruptive adolescents: a report of 10 cases.

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1
Department of Therapeutics, New York State Psychiatric Institute, New York 10032, USA.

Abstract

BACKGROUND:

To report an open trial of divalproex sodium in 10 adolescents with chronic temper outbursts and mood lability.

METHOD:

Ten adolescents meeting screening criteria for chronic temper outbursts and mood lability were followed for 5 consecutive weeks on open divalproex sodium treatment. Temper outburst frequency and mood swings severity at pretreatment and posttreatment were compared by using paired t tests. Subjects continued to be followed to judge persistence of response.

RESULTS:

All subjects showed clear improvement at 5 weeks and maintained it during follow-up while taking medication. Rapid relapse and recovery occurred in 5 of 6 patients who discontinued and then resumed medication.

CONCLUSION:

Divalproex sodium may be helpful in teenagers who have explosive tempers and severe mood swings, and benefits may generalize to school and family life.

PMID:
9055831
[Indexed for MEDLINE]
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