[Effect of five fluoroquinolones on the bactericidal activity of human polymorphonuclear leukocytes against Staphylococcus aureus]

Enferm Infecc Microbiol Clin. 1996 Dec;14(10):600-3.
[Article in Spanish]

Abstract

It has been evaluated the effect of norfloxacin, ofloxacin, levofloxacin, fleroxacin and lomefloxacin of the respiratory burst of human polymorphonuclear leukocytes and their intracellular activity against Staphylococcus aureus. None of these agents significantly affected the superoxide and hydrogen peroxide radicals production by the polymorphonuclear leukocytes. All the quinolones except norfloxacin showed significant intracellular activity against S. aureus.

Publication types

  • English Abstract

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Blood Bactericidal Activity / drug effects*
  • Fluoroquinolones
  • Humans
  • Respiratory Burst / drug effects*
  • Serum Bactericidal Test
  • Staphylococcus aureus* / drug effects

Substances

  • Anti-Infective Agents
  • Fluoroquinolones