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J Refract Surg. 1997 Jan-Feb;13(1):74-8.

Coralline hydroxyapatite keratoprosthesis in rabbits.

Author information

1
Barraquer Institute of America, Bogota, Colombia.

Abstract

BACKGROUND:

The ideal keratoprosthesis will have a curvature similar to that of the recipient cornea and allow the tissue to grow into the supporting material. We developed a support for a keratoprosthesis made of porous hydroxyapatite, which is highly biocompatible, biointegrable, non-biodegradable, and colonizable.

METHODS:

We implanted the keratoprosthesis unilaterally in the right eyes of 12 New Zealand rabbits, intralamellarly and between a homologous episclerokeratoplasty (with and without conjunctival flap) for 12 months. Pathology studies and technetium-99 bone scans were performed.

RESULTS:

We found good vascularization, no signs of infection or extrusion, no epithelial downgrowth, and no adverse tissue reaction.

CONCLUSION:

A clinical trial of this keratoprosthesis is warranted.

PMID:
9049939
[Indexed for MEDLINE]

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