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J Gen Virol. 1995 Jul;76 ( Pt 7):1877-84.

Molecular epidemiology of dengue-1 and dengue-4 viruses.

Author information

1
Institut Territorial de Recherches Medicales Louis Malardé, Tahiti, French Polynesia. chungue@pasteur.fr

Erratum in

  • J Gen Virol 1996 Mar;77(Pt 3):565-6.

Abstract

Genetic variation between geographically and temporally distinct isolates of dengue-1 (DEN-1) and dengue-4 (DEN-4) viruses was investigated. The nucleotide sequences of a fragment of the envelope protein gene encoding amino acids 28 to 87 of 35 DEN-1 isolates and 28 DEN-4 isolates were determined. Maximum nucleotide sequence variation was 6.9% and 4.9% for DEN-1 and DEN-4 viruses, respectively. Taking a divergence of 6% between the nucleotide sequences as the cut-off value, three genotype groups were defined for DEN-1 viruses, whereas only one was observed for DEN-4 viruses. Molecular analysis of isolates from the South Pacific permits the classification of the recent strains of DEN-1 (1988-1989 epidemics) into a genotype distinct from the genotype which comprises earlier strains. This observation suggests that the recent epidemics were due to the introduction of a new genotype rather than to the re-emergence of the earlier strain.

PMID:
9049396
DOI:
10.1099/0022-1317-76-7-1877
[Indexed for MEDLINE]

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