Format

Send to

Choose Destination
Trends Biochem Sci. 1997 Feb;22(2):59-63.

Protein misfolding in the cell envelope of Escherichia coli: new signaling pathways.

Author information

1
Centre National de Recherche Scientifique LIDSM, Marseille, France.

Abstract

Depending on their cellular localization, misfolded proteins in Escherichia coli trigger two different heat-shock responses. Cytoplasmic proteins induce the 'classical' heat-shock regulon transcribed by the E sigma 32 polymerase. By contrast, misfolding of proteins in the cell envelope induces the newly described E sigma E-dependent regulon. This implies that there is an inducible transduction machinery in the inner membrane. The response to protein misfolding in the cell envelope is a finely tuned system regulated by a cascade of phosphorylation and dephosphorylation reactions.

PMID:
9048484
DOI:
10.1016/s0968-0004(96)10072-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center