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Trends Biochem Sci. 1997 Feb;22(2):53-8.

ERM proteins: head-to-tail regulation of actin-plasma membrane interaction.

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1
College of Medical Technology, Kyoto University, Japan. atsukita@mfour.med.kyoto-u.ac.jp

Abstract

ERM (ezrin/radixin/moesin) proteins crosslink actin filaments with plasma membranes. The carboxyl termini of these proteins bind actin filaments, while the amino termini bind plasma membranes using a binding partner, such as CD44. Specific signals activate ERM proteins to bind actin filaments and the plasma membrane; these include phosphoinositides and/or phosphorylation mechanisms, which might be located downstream from the Rho-dependent pathway.

PMID:
9048483
[Indexed for MEDLINE]
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