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Trends Biochem Sci. 1997 Feb;22(2):39-42.

Aminoacyl-tRNA synthesis: divergent routes to a common goal.

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Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.


Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNA (by aminoacyl-tRNA synthetases) or indirectly by tRNA-dependent transformation of misacylated tRNAs. The accuracy of aminoacyl-tRNA synthesis is enhanced by a number of further protein-RNA or protein-protein interactions, some of which are restricted to Archaea, and might reflect adaptation mechanisms to diverse conditions.

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