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Bioessays. 1997 Feb;19(2):153-60.

Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions.

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Department of Biosciences, Karolinska Institute, Huddinge, Sweden.


The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.

[Indexed for MEDLINE]

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