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Bioessays. 1997 Feb;19(2):101-4.

Wnt signalling goes nuclear.

Author information

1
Abt. Biochemie, Universität Ulm, Germany.

Abstract

The Wnt signalling cascade is a highly conserved signalling pathway throughout the animal kingdom. In Xenopus, Wnt signalling functions in mesodermal dorsoventral patterning. Earlier work on deciphering the components of the wnt signalling cascade left a gap between cytosolic beta-catenin, the final member of the cascade, and the nuclear target genes. Several recent papers now reveal how the Wnt signal is transmitted into the nucleus. Surprisingly, beta-catenin directly interacts with the transcription factor LEF-1/XTCF-3, and thereby is not only translocated into the nucleus but also modulates the properties of LEF-1/XTCF-3 as a transcription factor.

PMID:
9046239
DOI:
10.1002/bies.950190204
[Indexed for MEDLINE]

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