Format

Send to

Choose Destination
Brain Res. 1997 Feb 7;747(2):324-7.

Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin.

Author information

1
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6085, USA.

Abstract

Charybdotoxin (ChTX), a venom protein, suppresses Ca2+-activated K+ (K+(Ca)) currents in the glomus cell of neonatal rat carotid body. If it works similarly for cat carotid body chemoreceptors, charybdotoxin is expected to stimulate the chemosensory discharge during normoxia, and particularly hypoxia and hypercapnia. We studied the effects of charybdotoxin (20-40 nM) in vitro (perfused/superfused) on the cat carotid chemosensory discharge, and simultaneously tissue PO2 (PtiO2), as a measure of positive control. ChTX (20 nM) only increased PtiO2 and decreased carotid chemosensory discharge during hypoxia, indicating vasodilation. We conclude that K+(Ca) channels do not appear to play a significant role in chemotransduction in the cat carotid body.

PMID:
9046009
DOI:
10.1016/s0006-8993(96)01313-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center