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Jpn J Cancer Res. 1996 Dec;87(12):1199-203.

Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts.

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Laboratory of Pathology, Aichi Cancer Research Institute, Chikusa-ku, Nagoya.


Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.

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