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Eur J Immunogenet. 1997 Feb;24(1):1-8.

An investigation of polymorphism in the interleukin-10 gene promoter.

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Tissue Typing Laboratory, St Mary's Hospital, Manchester, UK.


Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

[Indexed for MEDLINE]

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