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FEBS Lett. 1997 Feb 17;403(2):181-5.

The differentiation antigen Ly-6E.1 is expressed in mouse metastatic tumor cell lines.

Author information

1
Danish Cancer Society, Department of Molecular Cancer Biology, Copenhagen. cohn@biobase.dk

Abstract

We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.

PMID:
9042962
DOI:
10.1016/s0014-5793(97)00050-1
[Indexed for MEDLINE]
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