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J Pediatr. 1997 Feb;130(2):284-8.

Repeated invasive pneumococcal infections in young children without apparent underlying immunodeficiency.

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Crippled Children's Foundation Research Center, Le Bonheur Children's Medical Center, Memphis, TN 38103, USA.


During a 30-month interval at LeBonheur Children's Medical Center, 394 patients had a blood or cerebrospinal fluid culture positive for Streptococcus pneumoniae. Sixteen of these episodes (4%) were repeated infections; 6 of these 16 patients had sickle cell disease. Six of the remaining 10 patients had immunologic evaluations of varying completeness; no immunodeficiency was identified by these tests or on follow-up. Nine of the ten previously healthy patients with repeated pneumococcal disease were less than 2 years of age. In our experience, repeated invasive pneumococcal infections in otherwise healthy young children were relatively common (10/394, or 2.5% of patients with invasive pneumococcal infections) and did not indicate the presence of an unsuspected immunodeficiency.

[Indexed for MEDLINE]

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