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J Neuroimmunol. 1997 Feb;72(2):143-8.

Respective role of TNF receptors in the development of experimental cerebral malaria.

Author information

1
Dept. of Anaesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland.

Abstract

The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. The protection of Tnfr2null mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.

PMID:
9042106
DOI:
10.1016/s0165-5728(96)00185-3
[Indexed for MEDLINE]

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