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J Thorac Cardiovasc Surg. 1997 Feb;113(2):278-84.

Plasma neuropeptide Y and catecholamines in pediatric patients undergoing cardiac operations.

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1
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA.

Abstract

OBJECTIVE:

Our objective was to assess the sympathoadrenal response in pediatric patients undergoing repair of congenital cardiac defects.

METHODS:

Plasma catecholamine (norepinephrine and epinephrine) and neuropeptide Y concentrations were quantified before and after cardiopulmonary bypass to assess the response to cardiopulmonary bypass. To determine the response to aortic occlusion, levels of plasma catecholamines and neuropeptide Y were measured at the time of and immediately after release of the aortic crossclamp.

RESULTS:

During cardiopulmonary bypass, no significant change in levels of plasma norepinephrine (n = 43), epinephrine (n = 37), or neuropeptide Y (n = 46) was observed. Aortic occlusion induced a significant increase in plasma neuropeptide Y, but not in catecholamines. There was a greater increase in plasma neuropeptide Y in children older than age 1 year than in those younger than 1 year.

CONCLUSIONS:

Plasma neuropeptide Y may be a useful marker of sympathetic nervous system activity. Children younger than age 1 year showed a lesser sympathetic response compared with the response in older children.

PMID:
9040621
DOI:
10.1016/S0022-5223(97)70324-6
[Indexed for MEDLINE]
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