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Lancet. 1997 Feb 15;349(9050):490-5.

Chemokines: leucocyte recruitment and activation cytokines.

Author information

1
Liver Reseach Laboratories, University of Birmingham, Queen Elizabeth Hospital, UK. dh.adams@bham.ac.uk

Abstract

Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the generation of cellular inflammation, both in the protective responses to invading pathogens and in the pathological processes associated with infection and immune-mediated diseases. Chemokines are more than simple chemotactic factors, since they are also implicated in leucocyte activation, angiogenesis, and antimicrobial functions, including a protective role in HIV infection. These molecules provide potentially valuable targets for therapeutic intervention in a wide range of diseases.

PMID:
9040590
DOI:
10.1016/s0140-6736(96)07524-1
[Indexed for MEDLINE]

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