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Curr Opin Neurobiol. 1997 Feb;7(1):110-8.

Neurotrophin switching: where does it stand?

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School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9AJ, Scotland, UK.


In vitro and in vivo studies suggest that certain populations of neurons switch their survival requirements from one neurotrophin to another during an early stage in their development. Although there is good evidence for neurotrophin switching in sensory neurons, the evidence for switching in sympathetic neurons has become more controversial, as has the identity of the factors that regulate their responsiveness to particular neurotrophins.

[Indexed for MEDLINE]

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