Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 1997 Feb;7(1):70-4.

Tyrosine phosphorylation and axon guidance: of mice and flies.

Author information

1
Division of Biology 216-76, California Institute of Technology, Pasadena, California 91125, USA. desai@seqaxp.caltech.edu

Abstract

Recent genetic evidence suggests that tyrosine kinases and tyrosine phosphatases can control the guidance of specific growth cones. Within a family of related phosphatases or kinases, individual members can have partially redundant functions. Receptor phosphatases can work together at one guidance choice point, but in opposition at another. The specific combination of kinases and phosphatases active in a growth cone may be an important determinant of pathway choice. One mechanism by which these proteins could control guidance decisions is through regulation of adhesion between growth cones and axons.

PMID:
9039791
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center