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Curr Opin Immunol. 1997 Feb;9(1):57-63.

An innate view of gamma delta T cells.

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Department of Immunology, The Scripps Research Institute, IMM-8, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.


Findings made during the past few years demonstrate that gamma delta T cells apparently share with macrophages a propensity to recognize nonpeptidic molecules of the kind most commonly associated with microorganisms and stressed cells. In general, recognition of these antigens by gamma delta T cells involves the antigen receptor but does not require antigen presenting cells to express MHC gene products or to have a functional antigen processing machinery. Other recent advances continue to support the notion that gamma delta T cells can perform specialized functions related to the repair of tissue damage.

[Indexed for MEDLINE]

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