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Curr Opin Immunol. 1997 Feb;9(1):107-13.

Regulation of transcription of MHC class II genes.

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Department of Microbiology and Immunology, Emory University School of Medicine, 3131 Rollins Research Center, Atlanta, GA 30322, USA.


Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.

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