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Cell. 1997 Feb 21;88(4):459-69.

Genes expressed in neurons of adult male Drosophila.

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Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.


We have identified two genes, roX1 and roX2, whose expression in the adult fly is restricted to neurons of males. The two genes reside on the X chromosome, and each encodes an RNA with no apparent open reading frame. Both genes are physically linked to female-specific genes that encode proteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin family. The male-specific transcripts are positively regulated by the dosage compensation pathway in an all-or-none fashion. Our data suggest that the multimeric complex of dosage compensation proteins may operate in different ways on different sets of X-linked genes.

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