The authors analyzed the clinical and morphological picture of Kaposi's sarcoma in a patient aged 38 with involvement of the facial skin and right buccal mucosa. Published reports and their own findings brought the authors to a conclusion that such a form of the disease is rare, characterized by specific clinical and morphological features, and difficult to treat. The prognosis is unfavorable because of generalization of the process, the duration of the disease ranging from several months to 20 years.