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Nat Struct Biol. 1997 Feb;4(2):147-52.

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.

Author information

1
Division of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK.

Abstract

The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.

PMID:
9033596
[Indexed for MEDLINE]

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