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Trends Biotechnol. 1997 Jan;15(1):20-6.

Bacterial and archaeal S-layer proteins: structure-function relationships and their biotechnological applications.

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Center for Ultrastructure Research, Universität für Bodenkultur Vienna, Austria.


Crystalline cell surface layers (S-layers) composed of planar assemblies of protein or glycoprotein subunits are one of the most commonly observed cell envelope structures of bacteria and archaea. Isolated S-layer subunits of numerous organisms are able to assemble into monomolecular arrays either in suspension, at liquid-surface interfaces, including lipid films, on liposomes and on solid supports. Pores in S-layers are of regular size and morphology, and functional groups on the protein lattices are aligned in well-defined positions and orientations. These characteristic features of S-layers have led to various applications in biotechnology, vaccine development, diagnostics, biomimetics and molecular nanotechnology.

[Indexed for MEDLINE]

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